When you first open Excel and start using CDXStreamerTM, default settings will be used in the settings interface. After you successfully obtain market data, CDXStreamerTM will remember the last settings you used and automatically reload them in the settings interface. The only setting where this is not the case is the first index location, which is always the location of the active cell.
It is very easy to change the default settings to suit your needs - please refer to the help section under "Session Commands".